Covid infections in fully vaccinated ‘more severe in the immunocompromised’

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A new study suggests that oronavirus infection is rare in fully vaccinated people, but is more common and severe in people with weakened immune systems.

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The researchers analyzed health records and found that only 0.08% of people in their full vaccination pool experienced a successful infection between December 10, 2020, and July 8, 2021.

They also found that while immunocompromised individuals represented 18% of those studied, they accounted for more than 38% of infections, about 60% of all hospital admissions and 100% of deaths.


According to the study, the proportion of people with successful infection was three times higher in immunocompromised individuals (0.18%) than in the reference group of non-immunocompromised people (0.06%).

While the COVID-19 mRNA vaccines help protect people from becoming infected and seriously ill, the risk of successful infection in people who are fully vaccinated does not completely eliminate

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Lead author Manuela Di Fusco, from the Pfizer Health Economics and Results research team, said: “The results complement other real-world studies and support the introduction of a third dose of the COVID-19 vaccine to increase protection among immunocompromised individuals.

“Many countries are currently experiencing a resurgence of Sars-CoV-2 infection despite the rollout of large-scale vaccination programmes.

“While COVID-19 mRNA vaccines help protect people from becoming infected and seriously ill, the risk of successful infection is not completely eliminated in people who are fully vaccinated.”

Identifying individuals in the US population who received two doses of the Pfizer/BioNTech vaccine, the Pfizer study examined successful infection among those with and without weakened immune systems.

The team analyzed the health records of 1,277,747 people aged 16 or older who had received two doses of the jab.

In this group, 225,796 (17.7%) were identified as immunocompromised – including those with advanced HIV/AIDS, cancer, kidney disease, rheumatoid or other inflammatory conditions, other immune conditions, and bone marrow or organ transplant recipients .

Ms Di Fusco said: “The results of our study advance the understanding of post-vaccination outcomes and the recent recommendations for providing a third primary series dose of mRNA COVID-19 vaccine to patients with weakened immune systems after the initial two doses. support.”

Conclusion The UK’s Joint Committee on Immunization and Immunization (JCVI) announced that severely immunized people should be offered a booster dose no earlier than three months after completing their primary course of three doses.

This research is published in the Journal of Medical Economics.


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