Spice pill to ease misery of cystitis: Tablet made of cinnamon and is tested as treatment for the painful infection 

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A pill made from cinnamon, cranberries and ‘healthy’ bacteria is being tested as a way to prevent and treat cystitis.

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This common infection, which affects up to half of all women at some point, occurs when bacteria living harmlessly in the gut or on the skin enter the bladder through the urethra, the tube that carries urine out of the body. takes away.

Researchers believe that the combination of active ingredients will work together to stop E. coli and other bacteria responsible for the infection from sticking to the walls of the urinary tract.

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The theory is that the pill lays on the p-fimbria, tiny protrusions found on the surface of each bacterial cell that help anchor it to the walls of the urinary tract. The scientists behind the polypill say cranberry influences the formation of these protrusions—instead the bacteria lengthen and distort, making them difficult to grasp.

Trans-cinnamaldehyde (a component in cinnamon oil) and compounds in cranberries have also been shown in previous scientific research, including a study in the Journal of Urology in 2011, to help bacteria attack host tissue and bladder cells. to be prevented.

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Researchers believe that the combination of active ingredients will work together to prevent E. coli and other bacteria that are responsible for the infection from sticking to the walls of the urinary tract. [File photo]

The healthy bacteria in the polypil are thought to strengthen the immune cells in the wall of the bladder.

According to a study published last year in Therapeutic Advances in Urology, 50 to 60 percent of women suffer from a urinary infection such as cystitis at some point in their lives.

Women are most at risk because their urethra is shorter than that of men, which makes it easier for bacteria to reach the bladder. It can also become a more frequent and recurrent problem for women who have gone through menopause because falling estrogen levels cause tissue to become thinner, making it easier for bacteria to take hold.

Symptoms include burning or stinging during urination; urgent need to urinate; and dark, cloudy, or strong-smelling urine. It can make the affected people feel generally unwell, achy, sick and tired.

Treatment includes pain relievers and antibiotics. But finding the most appropriate and effective antibiotic for a patient can take time, and requires testing of samples in the lab. Medications can also cause side effects, such as diarrhea and nausea.

There is also an increasing problem of antibiotic resistance, with bacteria looking for ways to overcome drugs designed to kill them. The National Institute for Health and Care Excellence revealed in 2017 that 34 percent of one million NHS urinary tract infection samples were resistant to the antibiotic trimethoprim.

A pill made from cinnamon, cranberry (pictured) and 'healthy' bacteria is being tested as a way to prevent and treat cystitis.

A pill made from cinnamon, cranberry (pictured) and ‘healthy’ bacteria is being tested as a way to prevent and treat cystitis.

The new treatment is being tested at the Alfred Fournier Institute in Paris on 80 women aged 18 to 65 who have had at least two episodes of cystitis during the past six months, and whose quality of life is significantly reduced. Is.

They would be given two pills a day and compared to a control group of similar women who did not take the pill. Researchers will compare the number of cystitis infections and symptoms in the two groups over six months. The result is expected next year.

Professor Raj Prasad, a consultant urologist at Bristol Urology Associates, believes the new pill shows promise.

He says one hypothesis about recurrent cystitis is that ‘some bacteria stick to the inside of the bladder wall and can become infected again if not completely treated’.

He added, ‘This new therapy proposes to loosen the hold of bacteria on the bladder wall.’

A type of bacteria found in the vagina can prevent recurrent cystitis.

In a new study, using a vaginal suppository containing Lactobacillus crispatus two to three times a week for one year helped prevent attacks, reports the International Journal of Urology.

The treatment not only stopped the attacks over the course of 12 months, but was also protective over the following year. The researchers suggest that Lactobacillus crispatus flushes out the bad bacteria in the muscles and stops them from taking hold.

lockdown legacy

Permanent impact of pandemic shutdown. This week: worsening tinnitus

Tinnitus, which causes ringing or other noises in the ears for no apparent reason, has worsened for nearly half of sufferers due to the lockdown, research has found.

In a study of 3,000 patients published last November in Frontiers in Public Health, 40 percent had worse symptoms during the lockdown.

Dr Aldre Beyux, a lecturer in audiology at Anglia Ruskin University who led the study, said: “Those who found the lockdown or pandemic stressful or for whom it raised financial or health concerns were most likely to have worsened tinnitus. Was.” ‘Tinnitus and emotional distress can trigger or worsen each other.’

She suggests that cognitive behavioral therapy (talking therapy) and mindfulness may also be worth discussing with a professional. Online groups for tinnitus sufferers can also help combat isolation.

do it

Look at the bright side — in a new 12-year study, researchers found that people who developed cognitive impairment, such as dementia, were less likely to report better psychological well-being (which included being optimistic and having social support). was), according to the Journal of Aging and Health.

take hold

Terms related to the strength in your hand. This week: Covid-19

According to a study published in the Heart and Lung journal in June, one’s response to catching COVID-19 can be predictable, with people with a weak catch being three times more likely to have a serious infection.

A separate study found that grip strength is also related to the risk of hospitalization from Covid-19 in those over 50, reports the Journal of Cachexia, Sarcopenia and Muscle.

‘Grip strength is an important sign…

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