The man who can NEVER gain weight: Scottish teenager, 18, has ultra rare condition which prevents fatty tissue being stored under the skin and affects just 13 people worldwide 

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  • Dylan Lombard, 18, of Glasgow, first developed symptoms of MDP as a child
  • It is caused by a single gene mutation that triggers unrelated conditions including weight loss, type 2 diabetes and fused bones.
  • Reveals how mother saw her ‘losing a lot of weight’ and got ‘very worried’
  • Said: ‘It took me 10 years for a doctor to diagnose the condition’
  • Revealed that growing up was ‘really hard’ because ‘people would laugh at that’

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A Scottish teen has revealed how her body is unable to store fat due to one of the world’s rarest conditions – which affects just 13 people worldwide.

Dylan Lombard, 18, of Glasgow, developed the first symptoms of MDP – with mandibular hypoplasia, deafness and progeroid features – when he was 18 months old, but was not diagnosed until 10 years after ‘constant’ doctors’ appointments.

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The condition – which affects just one in six hundred million people worldwide – prevents fatty tissue from accumulating under the skin, and results in a shortened lower jaw, ears, deafness, and skin tightening.

Dylan reveals: ‘Growing up it’s been really hard to see people stare, laugh and treat me differently, but I’ve learned that as I get older, I don’t let it affect me. Gave.’

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Dylan Lombard, 18, of Glasgow, Scotland, has opened up about his life with an extremely rare condition – which affects just 13 people worldwide – because his body is unable to store fat

The teenager began to develop symptoms of MDP – with mandibular hypoplasia, deafness and progeroid features – when he was 18 months old.

The teenager began to develop symptoms of MDP – with mandibular hypoplasia, deafness and progeroid features – when he was 18 months old (left) but was not diagnosed until 10 years after 'constant' doctors' appointments (right) Was.

The teenager began to develop symptoms of MDP – with mandibular hypoplasia, deafness and progeroid features – when he was 18 months old (left) but was not diagnosed until 10 years after ‘constant’ doctors’ appointments (right) Was.

Dylan said growing up was 'really hard' because people would 'stare and laugh' at him because of his appearance

Dylan said growing up was ‘really hard’ because people would ‘stare and laugh’ at him because of his appearance

MDP syndrome is an extremely rare and complex condition and is known to affect only a small number of people in the world.

Dylan and other patients found an abnormality in the POLD1 gene that leads to a defective enzyme important for DNA replication.

He said: ‘I was born with the condition, but it didn’t show up until I was 18 months old.

‘My mother noticed me losing a lot of weight and got very worried.

Dylan was born with the rare condition, but it didn't appear until he was 18 months old

Dylan was born with the rare condition, but it didn't appear until he was 18 months old

Dylan was born with the rare condition, but it didn’t appear until he was 18 months old (pictured left and right as a baby)

Teenager diagnosed after her mother noticed she had lost a lot of weight and became 'very worried'

Teenager diagnosed after her mother noticed she had lost a lot of weight and became ‘very worried’

MDP syndrome: extremely rare metabolic disorder that prevents fatty tissue from accumulating under the skin and affects 13 people worldwide

MDP syndrome, also known as mandibular dysplasia with deafness and progeroid features, is an extremely rare metabolic disorder that prevents fatty tissue from accumulating under the skin.

It is known to affect only a very small number of people around the world.

Recent research has suggested that this may be due to an abnormality of the POLD1 gene on chromosome 19, causing an enzyme important for DNA replication to become defective.

Symptoms:

  • mandibular hypoplasia (a small lower jaw),
  • Deafness,
  • skin tightening,
  • lipodystrophy (decreased fat under the skin),
  • low testosterone levels in men,
  • Stiffness in the claw toes and joints occurs as a result of the contraction of the long tendons of the toes.

In 2013, scientists diagnosed Tom Staniford, one of Britain’s leading para-athletes, with MDP syndrome.

31-year-old Tom was born at a normal weight, but lost all the fat around his face and limbs during his childhood and adolescence.

31-year-old Tom Staniford was born at a normal weight, but lost all the fat around his face and limbs during childhood and adolescence.

31-year-old Tom Staniford was born at a normal weight, but lost all the fat around his face and limbs during childhood and adolescence.

Her condition means she has no natural cushioning on her body, pain in her legs, and an increased risk of breaking bones when she falls.

Speaking to MailOnline in 2013, he said: ‘In some ways, it should not be important to identify the syndrome behind my symptoms – a name is just a name, but it is reassuring to know that there are others with the condition. And that we can lead relatively normal lives,” he said.

‘However, what may prove important is being able to classify me appropriately in competitions so that I do not compete against others at an unfair disadvantage.’

Researchers at the University of Exeter, where Tom studied law, compared the cyclist’s entire genetic code with that of three other patients with similar symptoms. The DNA of their family members was also analyzed.

Professor Andrew Hattersley, senior investigator from the Wellcome Trust at the university’s medical school, said: ‘Tom’s condition has been an enigma to us for many years. We could see symptoms, which included a very unusual case of type 2 diabetes in someone with obvious body fat, but didn’t know what caused them.

‘We had to look at 30 million base pairs (the chemical component of DNA) in Tom’s DNA and similar numbers in his family members and other patients to identify the single mutation. This would not have been possible even two years ago.

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‘It took me 10 years for a doctor to diagnose this condition after frequent visits due to ambiguity.

‘There are only 12 other people in the world who have MDP besides me, but when we got the diagnosis, we were relieved because we finally knew what it was.’

The physical effects of the condition mean that Dylan has often experienced people staring at or commenting on his appearance.

Although he added: ‘I surround myself with people who support and love me for who I am which is the best feeling in the world.’

However, despite the condition being apparent when Dylan was a child, it took a doctor 10 years to diagnose him because of his ambiguity.

However, despite the condition being apparent when Dylan was a child, it took a doctor 10 years to diagnose him because of his ambiguity.

The physical effects of the condition mean that Dylan has often experienced people staring at or commenting on his appearance.

The physical effects of the condition mean that Dylan has often experienced people staring at or commenting on his appearance.

The physical effects of the condition mean that Dylan has often experienced people staring at or commenting on his appearance.

Dylan reveals that when he finally got the diagnosis, he just 'felt relieved' that he knew what the condition was like

Dylan revealed that…

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